Tsanangudzo

Hydrochlorothiazide (HCTZ), mumuromo unoshanda diuretic mushonga wekirasi yethiazide, inhibit kushandura TGF-β/Smad kusaina nzira. Hydrochlorothiazide ine yakananga vascular relaxant mhedzisiro kuburikidza nekuvhura kwe calcium-activated potassium (KCA) chiteshi. Hydrochlorothiazide inovandudza kushanda kwemwoyo, inoderedza fibrosis uye ine antihypertensive effect.

Background

Hydrochlorothiazide ndeye diuretic mushonga wekirasi yethiazide.

In Vitro

Hydrochlorothiazide ndeye thiazide kirasi ye diuretics. Inoderedza huwandu hweropa nekuita paitsvo kuderedza sodium (Na) reabsorption mu distal convoluted tubule. Nzvimbo huru yekuita mu nephron inoonekwa pane electroneutral Na + -Cl co-transporter nekukwikwidza nzvimbo ye chloride pane mutakuri. Nekukanganisa Na kutakura mu distal convoluted tubule, hydrochlorothiazide induces a natriuresis uye concomitant kurasikirwa kwemvura. Thiazides inowedzera kudzoreredzwa kwecalcium muchikamu ichi nenzira isingaenderane nekutakura sodium. Pamusoro pezvo, nedzimwe nzira, Hydrochlorothiazide inofungidzirwa kuti inoderedza peripheral vascular resistance.

Hydrochlorothiazide (HCTZ; orally bygavage; 12.5 mg/kg/d; 8 weeks) yakavandudza kushanda kwemwoyo, yakaderedza cardiac interstitial fibrosis uye collagen volume fraction, yakaderera kutaura kweAT1, TGF-β uye Smad2 mumatishu emwoyo mumurume mukuru Sprague Dawley makonzo. Mukuwedzera, hydrochlorothiazide inoderedza plasma angiotensin II uye aldosterone mazinga. Uyezve, hydrochlorothiazide inhibits angiotensin II-induced TGF-.β1 uye Smad2 mapuroteni kutaura mune neonatal rat ventricular fibroblasts.

Chimiro chemakemikari