Mumakore achangopfuura, kutengesa kweapixabandzakakura nekukurumidza, uye musika wepasi rose wakatopfuurarivaroxaban.Nekuti Eliquis (apixaban) ine mukana pane warfarin mukudzivirira sitiroko uye kubuda ropa, uye Xarelto (Rivaroxaban) vaingoratidza kusadzikisira.Pamusoro pe,Apixabanhaidi kurongeka kwedosi yakaoma, uye mushonga wacho uri nyore.Iyi nhevedzano yezvakaipira zvakakonzerarivaroxabankurasikirwa pasi mumusika weUS.

Zvisinei, munyika yeChina.rivaroxabanine zvimwe zviratidzo pasi rose uye mu mainland China.Iyo patent inopera nguva yerivaroxabaniri pedyo, uye kuwanikwa kwemushonga kuchakonzera ruzhinji rwerivaroxabangeneric mishonga yekupfuura zvakanyanya iyo yeApixaban.

Zvinoenderana nedata reXianda, musika wekutengesa werivaroxaban muna 2018 waive 2.8 bhiriyoni yuan.Zvinoenderana nechiziviso cheHuahai Pharmaceutical, musika wemuchipatara musika wekutengesa werivaroxabanmuna 2018 aive 1.527 bhiriyoni yuan.

Ehe, kunyorwa kwemishonga yegeneric kunotungamira mukudonha kwakanyanya kwemutengo wezuva rimwe chete werivaroxaban.Tichifunga kuti pakati pemaNOAC ese, patents erivaroxabanmakomisheni anopera basa muna 2020 pakutanga (patents forapixabanuye dabigatran etexilate yakareba Kwenguva refu), pasina mubvunzo zvichabatsira mukusimudzirwa kwakazara.rivaroxabangeneric mishonga yekutsiva warfarin.Kana mutengo wezuva nezuva werivaroxabangeneric drugs inotangwa kubva pa27.6 yuan kusvika 2.76 yuan, maitiro aya achasimbiswawo.

Huwandu hwemashandisirwo anongofunga varwere vane atrial fibrillation (AF) zvakare zvinoshamisa.Huwandu hwevarwere vane atrial fibrillation muChina hunosvika mamirioni gumi, avo vangangoita miriyoni maviri ndeye valvular atrial fibrillation uye vangangoita mamirioni manomwe kune isiri-valvular atrial fibrillation.Ongororo muna 2016 Zvinoonekwa kuti mwero wekuziva kweatrial fibrillation muMainland China i40%, uye anticoagulation rate i30%.Rivaroxaban iri nyore kushandisa, haidi kugarotariswa kweiyo coagulation zviratidzo, uye iyo anticoagulation rate inozovandudzwawo zvakanyanya.Zvinofungidzirwa kuti generic mushonga werivaroxabanichave muMainland China.Saizi yemusika inoshandiswa muvarwere vane non-valvular atrial fibrillation uye atrial fibrillation: 7 miriyoni varwere * 30% anticoagulation rate * 50% yekupinda mwero * 2.76 yuan / zuva * 365 mazuva = 157 miriyoni yuan.

Pamusoro pezvo, tarisiro yemusika yekudzivirira uye kurapwa kwevarwere veVTE inodzikiswa.Maererano nehuwandu hweVTE Prevention and Treatment Center muUnited States, nhamba yevarwere veVTE muUnited States yakakwira kusvika 900,000 gore negore, uye nhamba yevanhu vanofa neVTE inosvika 60,000 kusvika ku100,000, uye kune zvinetso zvenguva refu (Zvakadai seDVT) varwere vakaverengera 50%, uye nhamba yekudzokazve mukati memakore gumi yakaverengera 33%.

Nekuda kwekuchembera kwehuwandu hweChina, uye huwandu hwehuwandu hwevanhu hunodarika 4 nguva yeUnited States (1.395 bhiriyoni vanhu).Zvinogona kufanotaurwa kuti kune 3.6 miriyoni VTE varwere muChina gore rega rega.Tichifunga kuti 3-mwedzi kurapwa mwero werivaroxabaniri 80%, saizi yemusika ndeye: 3.6 miriyoni varwere * 80% kurapwa mwero * 2.76 yuan/zuva * 92 mazuva = 731 miriyoni yuan.

Naizvozvo, tichingoverengera zviratidzo zviviri zveAF neVTE, saizi yemusika wemba yerivaroxaban generic mishonga iri pedyo nemabhiriyoni maviri eyuan.Zvakakwana kuita kuti makambani epamba emishonga akurumidze kunyorera kunyorwa.

Isu,Changzhou Pharmaceutical Factory, gadzirawoapxiabanuyerivaroxban, uye vese vane DMF.Rivaroxabaniri pasi pekugadzirisa kushandisa CEP neWC.