Ruxolitinibimhando yemushonga wegomarara unonangwa.Inonyanya kushandiswa kuvharidzira kushandiswa kweJAK-STAT yekusaina nzira uye kudzikisa chiratidzo chinodzvanya kuwedzeredza kusingaite, nekudaro kuwana kurapa.Inoshanda nekuvhara muviri wako kubva pakugadzira zvinhu zvinonzi kukura zvinhu.Haikwanise kurapa chirwere chimwe chete munzvimbo yehematology yekurapa, asiwo kurapa classical myeloproliferative neoplasms (inonziwo BCR-ABL1-negative MPNs), JAK exon 12 mutations, CALR, uye APL, nezvimwewo.
Chii chinokurudzirwa kutanga dose?
Inogona kukonzera mhedzisiro inosanganisira myelosuppression zvakare, zvichikonzera zvisingawanzo, asi zvingangove zvakakomba kiriniki zviratidzo zvakaita seneutropenia, thrombocytopenia, leukemia uye anemia.Saka kunyanya kuchenjerera kunofanirwa kutorwa pakuona kutanga madosi kana uchinyorera varwere.Iyo yakakurudzirwa kutanga dose yeRuxolitinib inonyanya kuenderana nemurwere PLT kuverenga.Kune varwere vane platelet count inopfuura 200, iyo yekutanga dose ndeye 20 mg kaviri pazuva;kune avo vane platelet count muhuwandu hwe100 kusvika ku200, iyo yekutanga dose ndeye 15 mg kaviri zuva nezuva;Kune varwere vane nhamba yeplatelet iri pakati pe50 ne100, iyo yakakura yekutanga dose ndeye 5 mg kaviri pazuva.
Chengetedzo usati watoraRuxolitinib
Chekutanga, sarudza chiremba ane ruzivo rwakapfuma mukurapa neRuxolitinib.Udza chiremba wako kana iwe uri allergic kwairi, kana iwe uine chero mamwe allergies.Inogona kunge iine zvinhu zvisingaite, izvo zvinogona kukonzera kusawirirana kana mamwe matambudziko.
Kechipiri, gara uchiyedza yako PLT kuverenga.Kuverengera kweropa kuzere uye kuverengerwa kweplatelet kunofanirwa kurekodhwa ega ega mavhiki 2-4 kubva pakutora Ruxolitinib kusvika madosi agadzikana, uye wozoongororwa kana zviratidzo zvekiriniki zvichida kudaro.
Chechitatu, gadzirisa madosi nemazvo.Mushonga wekutanga hauwanzogadziriswa kana ukatora Ruxolitinib asi uine yakaderera platelet count pakutanga.Kana nhamba yako yePLT ichikwira sezvo yakanangwa yekubatanidza therapy inoenderera, unogona kuwedzera zvishoma nezvishoma dosi rako nekutevera mirairo yachiremba wako zvakanyatsonaka.
Chekupedzisira, udza chiremba wako nhoroondo yako yekurapa, kunyanya ye myeloproliferative kusagadzikana senge chirwere cheitsvo, chirwere chechiropa, uye kenza yeganda.Mimwe mishonga kana marapirwo anofanirwa kutsiva Ruxolitinib kana iwe usina kukodzera.
Nguva yekutumira: Kubvumbi-25-2022