Kukundikana kwemoyo nechikamu chakaderedzwa ejection (HFrEF) imhando huru yekutadza kwemoyo, uye China HF Chidzidzo chakaratidza kuti 42% yekutadza kwemoyo muChina iHFrEF, kunyangwe akati wandei makirasi ekurapa emishonga aripo kune HFrEF uye akadzikisa njodzi. yerufu uye kuchipatara nekuda kwekutadza kwemoyo kusvika pamwero wakati.Nekudaro, varwere vari panjodzi huru yekudzokororwa kwemoyo kutadza kuwedzera zviitiko, kufa kunoramba kuri kwakatenderedza 25% uye kufungidzira kunoramba kuri kushoma.Naizvozvo, pachine kudiwa kwekukurumidzira kwevamiriri vatsva vekurapa mukurapwa kweHFrEF, uye Vericiguat, inova soluble guanylate cyclase (sGC) stimulator, yakadzidzwa muchidzidzo cheVICTORIA kuona kana Vericiguat inogona kuvandudza kufungidzira kwevarwere vane HFrEF.Chidzidzo chacho chakawanda, randomized, parallel-group, placebo-controlled, double-mapofu, chiitiko-chinotungamirirwa, chikamu chechitatu chekliniki yemigumisiro yekudzidza.Yakaitwa pasi pechirongwa cheVIGOR Center muCanada pamwe nekubatana neDuke Clinical Research Institute, nzvimbo dze616 munyika dze42 nematunhu, kusanganisira Europe, Japan, China neUnited States, vakapinda muchidzidzo ichi.Dhipatimendi redu rehutano hwemwoyo rakakudzwa kutora chikamu.Huwandu hwevarwere ve5,050 vane chirwere chemoyo chisingaperi vane makore ≥18 makore, NYHA kirasi II-IV, EF <45%, ine yakakwira natriuretic peptide (NT-proBNP) mazinga mukati memazuva makumi matatu isati yaitika, uye vaive muchipatara nekuda kwekukundikana kwemoyo. mukati memwedzi ye6 isati yaitwa randomisation kana kuti diuretics inoshandiswa intravenously nokuda kwekukundikana kwemoyo mukati memwedzi ye3 vasati vaita randomisation vakanyoreswa muchidzidzo, vose vachigamuchira ESC, AHA / ACC, uye nyika / nharaunda nhungamiro dzakakurudzirwa.Varwere vakaverengerwa muchiyero che1: 1 kumapoka maviri uye vakapihwaVericiguat(n=2526) uye placebo (n=2524) pamusoro pekurapa kwakajairwa, zvichiteerana.
Mhedzisiro yekutanga yekudzidza yaiva iyo yakasanganiswa yekuguma kwekufa kwemoyo kana kutanga kwekushaya moyo muchipatara;magumo echipiri aisanganisira zvikamu zvekutanga kwekupedzisira, kutanga uye kunotevera kurwara kwemoyo kuchipatara (zviitiko zvekutanga uye zvinowanzoitika), kuguma kwekupedzisira kwezvose-zvinokonzera rufu kana kuora mwoyo kuchipatara, uye zvose-zvinokonzera rufu.Pakutevera kwepakati pemwedzi ye10.8, pakanga pane kuderedzwa kwe10% mumagumo ekupedzisira ekufa kwemwoyo kana chirwere chekutanga chekushaya mwoyo muchipatara muboka reVericiguat zvichienzaniswa neboka re placebo.
Kuongororwa kwemagumo ekupedzisira kwakaratidza kuderera kukuru kwekushaya mwoyo kuchipatara (HR 0.90) uye kuderera kukuru kwekupedzisira kwekupedzisira kwezvose-zvinokonzera rufu kana kushaya mwoyo kuchipatara (HR 0.90) muboka reVericiguat kana ichienzaniswa neboka re placebo.
Zvigumisiro zvechidzidzo zvinoratidza kuti kuwedzerwa kweVericiguatkusvika pakurapa kwakajairwa kwekukundikana kwemoyo zvakanyanya kunoderedza kuitika kwechangobva kuitika kwekuipa kwekutadza kwemoyo zviitiko uye kunoderedza njodzi yekuumbwa kwekupedzisira kwemoyo wemoyo kufa kana kuchipatara nekuda kwekutadza kwemoyo kune varwere vane HFrEF.Kukwanisa kweVericiguat kuderedza dambudziko rekupedzisira kwekufa kwemoyo kana kuparara kwemoyo muchipatara kune varwere vane njodzi huru yekukundikana kwemoyo inopa nzira itsva yekurapa kwekukundikana kwemoyo uye inozarura nzira itsva dzekutsvaga kwekutsvaga kwechirwere chemoyo.Vericiguat haisati yatenderwa kushambadzira.Kuchengetedzeka, kushanda nesimba uye kudhura kwemushonga kuchiri kuda kuongororwa pamusika.
Nguva yekutumira: Feb-09-2022