Iyo nzira yekurapa yekutanga myelofibrosis (PMF) yakavakirwa pane njodzi stratification.Nekuda kwekusiyana kwezviratidzo zvekiriniki uye nyaya dzinofanirwa kugadziriswa muvarwere vePMF, nzira dzekurapa dzinoda kutarisisa chirwere chemurwere uye zvinodiwa zvekiriniki.Kutanga kurapwa neruxolitinib (Jakavi / Jakafi) kune varwere vane spleen yakakura yakaratidza kuderera kukuru kwespleen uye yakanga yakasununguka kune mutyairi kuchinja mamiriro.Hukuru hukuru hwekuderedzwa kwespleen hunoratidza kufungidzira kuri nani.Mune varwere vane njodzi yakaderera vasina chirwere chakakosha chekiriniki, vanogona kucherechedzwa kana kupinda muzviedzo zvekiriniki, nekudzokorora kuongororwa mwedzi yese ye3-6.Ruxolitinib(Jakavi / Jakafi) kurapa kwezvinodhaka kunogona kutangwa mune yakaderera- kana yepakati-ngozi-1 varwere vanouya ne splenomegaly uye / kana chirwere chechipatara, maererano neNCCN mirayiridzo yekurapa.
Kune yepakati-ngozi-2 kana yakanyanya-panjodzi varwere, allogeneic HSCT inosarudzwa.Kana kuisirwa kusingawanikwi, ruxolitinib (Jakavi/Jakafi) inokurudzirwa seyokutanga mutsara wekurapa sarudzo kana kupinda mumakiriniki miedzo.Ruxolitinib (Jakavi/Jakafi) ndiyo yega mushonga unobvumidzwa pasi rese unonangana neakawandisa JAK/STAT nzira, iyo pathogenesis yeMF.Zvidzidzo zviviri zvakabudiswa muNew England Journal uye Journal of Leukemia & Lymphoma zvinoratidza kuti ruxolitinib (Jakavi / Jakafi) inogona kuderedza zvakanyanya chirwere ichi nekuvandudza hupenyu hwevarwere vane PMF.Mukati-mungozi-2 uye vane ngozi yeMF varwere, ruxolitinib (Jakavi / Jakafi) yakakwanisa kuderedza spleen, kuvandudza zvirwere, kuvandudza kurarama, nekuvandudza mapfupa emapfupa, kusangana nezvinangwa zvekutanga zvekugadzirisa zvirwere.
PMF ine chiitiko chegore negore che 0.5-1.5 / 100,000 uye ine yakaipisisa prognosis yevose MPNs.PMF inoratidzirwa ne myelofibrosis uye extramedullary hematopoiesis.MuPMF, bone marrow fibroblasts haibvi kubva kune asina kujairika clones.Inenge chikamu chimwe muzvitatu chevarwere vane PMF havana zviratidzo panguva yekuongororwa.Zvichemo zvinosanganisira kuneta kwakanyanya, kupererwa neropa, kusagadzikana mudumbu, manyoka nekuda kwekutanga kuguta kana splenomegaly, kubuda ropa, kuonda, uye peripheral edema.Ruxolitinib(Jakavi/Jakafi) yakagamuchirwa muna Nyamavhuvhu 2012 yekurapa kwepakati kana yakanyanya njodzi myelofibrosis, kusanganisira yekutanga myelofibrosis.Mushonga uyu unowanikwa munyika dzinodarika makumi mashanu pasi rose.