Myelofibrosis (MF) inonzi myelofibrosis.Ichowo chirwere chisingawanzoitiki.Uye chikonzero chechirwere chayo hachizivikanwi.Makiriniki anoratidza vechidiki masero matsvuku eropa uye pwere granulocytic anemia ine huwandu hwemisodzi inodonha masero matsvuku eropa.Bone marrow aspiration inowanzo ratidza kuoma kweshuviro, uye spleen inowanzowedzera zvakakura nemhando dzakasiyana dze osteosclerosis.
Primary myelofibrosis (PMF) inonzi clonal myeloproliferative disorder (MPD) yehematopoietic stem masero.Kurapa kweprimary myelofibrosis kunonyanya kutsigira, kusanganisira kuwedzerwa ropa.Hydroxyurea inogona kupihwa kune thrombocytosis.Yakaderera-njodzi, asymptomatic varwere vanogona kucherechedzwa pasina kurapwa.
Zvidzidzo zviviri zvechikamu chechitatu (STUDY1 uye 2) zvakaitwa kune varwere vane MF (primary MF, post-geniculocytosis MF, kana post-primary thrombocythemia MF).Muzvidzidzo zvese zviri zviviri, varwere vakanyoresa vaive ne splenomegaly inonzwisisika ingangoita masendimita mashanu pazasi pembabvu uye vaive vari pakati nepakati (2 prognostic factor) kana njodzi yakanyanya (3 kana zvimwe zvinotarisisa zvinhu) zvinoenderana neInternational Working Group consensus criteria (IWG).
Chiyero chekutanga cheruxolitinib chinobva pahuwandu hweplatelet.15 mg kaviri pazuva kune varwere vane maplatelet anoverenga pakati pe100 ne200 x 10 ^ 9/L uye 20 mg kaviri pazuva kune varwere vane maplatelet anodarika 200 x 10 ^ 9/L.
Mishonga yega yega yakapiwa maererano nekushivirira uye kushanda kwevarwere vane platelet kuverenga pakati pe100 ne125 x 10 ^ 9 / L, ine chiyero chikuru che 20 mg kaviri zuva nezuva;kune varwere vane maplatelet kuverenga pakati pe75 ne100 x 10 ^ 9 / L, 10 mg kaviri pazuva;uye kune varwere vane maplatelet anoverenga pakati pe50 uye zvishoma kudarika kana kuenzana ne75 x 10 ^ 9 / L, 2 nguva zuva nezuva pa5mg nguva imwe neimwe.
Ruxolitinibndeyemumuromo JAK1 uye JAK2 tyrosine kinase inhibitor yakagamuchirwa muEuropean Union muna Nyamavhuvhu 2012 yekurapa kwepakati kana yakanyanya njodzi myelofibrosis, kusanganisira primary myelofibrosis, post-geniculocytosis myelofibrosis uye post-primary thrombocythemia myelofibrosis.Parizvino, ruxolitinib Jakavi inotenderwa munyika dzinopfuura makumi mashanu pasirese, kusanganisira European Union, Canada uye akati wandei Asia, Latin uye South America nyika.