Ruxolitinib rudzi rweoral targeted therapy inonzi kinase inhibitor uye inonyanya kushandiswa kurapa zvirwere zvakadai segraft-versus-host disease, erythroblastosis, uye yepakati-uye-yakanyanya-ngozi myelofibrosis, nepo Ruxolitinib cream is a topical dermatological agent iyo inoshandiswa. zvakananga paganda kurapa eczema, vitiligo, atopic dermatitis, uye mhanza. Kunyangwe Ruxolitinib neRuxolitinib cream zvakasiyana zvakanyanya kubva kune mumwe nemumwe, zviri nyore kuvhiringika nekuti vane zita rakafanana. Changzhou Pharmaceutical Factory (CPF), inotungamiraRuxolitinib mutengesimuChina, pano inoongorora misiyano iri pakati pavo maererano nezvikamu zvitatu zvikuru kuti ikubatsire kuziva zvakawanda nezvavo.
1. Chiratidzo
Ruxolitinibyakabvumidzwa neFDA muna Mbudzi 2011 uye neEuropean Commission muna Nyamavhuvhu 2012 uye imhando yemushonga wakanangwa une zviratidzo chaizvo. Inoshandiswa kurapa varwere vane marudzi matatu ezvirwere, kusanganisira steroid-refractory acute graft-versus-host disease, erythroblastosis, uye moderate-to-high ngozi myelofibrosis (MF). Asi Ruxolitinib cream iri padanho rekusimudzira uye inotadza kuenda kumusika, saka mushonga wepamusoro wekurapa chirwere cheshin uye mhanza uye haisati yave yakatenderwa zviratidzo. Nekudaro, zvidzidzo zvakaratidza kunaka kwekiriniki yeRuxolitinib mukurapa vitiligo, atopic dermatitis uye mhanza yakaoma.
2. Nzira yekushandisa
Ruxolitinib is oral kinase inhibitor inoshanda sediki molecule inhibitor yeprotein kinases JAK1 neJAK2, uye ndiyo yekutanga mushonga unobvumidzwa neFDA kurapa myelofibrosis. Asi Ruxolitinib cream ndeye topical application cream iyo inosiyana zvakanyanya kubva kuRuxolitinib nenzira yainoshandiswa nayo.
3. Side effect
Ruxolitinib ine mhedzisiro yakajeka. Izvo zvinowanzoitika zvehematologic side effects zvine chekuita nekushandiswa kwayo kuderedzwa kweplatelet count uye anemia, uye inowanzozivikanwa isiri yehematologic side effects ndeye petechiae, dzungu, uye musoro. Nekudaro, Ruxolitinib cream ichiri mukuyedzwa kwekiriniki, saka mhedzisiro yayo haina kutsanangurwa.
Bata CPF kuti utore Ruxolitinib nemutengo unokwanisika, uye enda kukiriniki yekuyedza kunyorera mushandirapamwe kuti utore Ruxolitinib kirimu mahara.
Nguva yekutumira: May-12-2022