2. Thalidomide mu bundu cachexia
Oncologic cachexia, chirwere chegomarara chepamusoro chinoratidzwa neanorexia, kupera kwetishu uye kudzikira uremu, idambudziko rakakura mukutarisirwa kwegomarara repamusoro.
Nekuda kwehupenyu hupfupi uye hurombo hwehupenyu hwevarwere vane kenza yepamusoro, nhamba yezvidzidzo muzvidzidzo zvekiriniki idiki, uye zvidzidzo zvakawanda zvakangoongorora kushanda kwepedyo-nguva uye pedyo-nenguva yakaipa mhedzisiro yethalidomide, saka iyo yakareba- kushanda kwenguva uye kwenguva refu yakaipa mhedzisiro yethalidomide mukurapa oncologic cachexia ichiri kudikanwa kuongororwa mumakiriniki ekuedzwa ane hukuru hwesample saizi.
3. Migumisiro yakaipa ine chokuita nekurapa kwethalidomide
Kuita kwakashata senge chemotherapy-inoenderana nekusvotwa uye kurutsa zvinogona kukanganisa kushanda kwechemotherapy uye kuderedza hupenyu hwevarwere.Kunyange zvazvo neurokinin 1 receptor antagonists inogona kuvandudza zvakanyanya maitiro asina kunaka akadai sekusvotwa uye kurutsa, kushandiswa kwavo kwekliniki nekusimudzirwa kwakaoma nekuda kwehutano hwevarwere uye zvimwe zvikonzero.Naizvozvo, kutsvaga mushonga wakachengeteka, unoshanda uye usingadhuri wekudzivirira uye kurapa chemotherapy-inosanganisirwa nausea uye kurutsa rave dambudziko rekukurumidzira rekiriniki.
4. Mhedziso
Nekuenderera mberi kwekutsvagisa kwekutanga uye kwekiriniki, kushandiswa kwethalidomidemukurapwa kwemamota akasimba akajairika kwave kuwedzera, uye kushanda kwayo kwekiriniki nekuchengetedzeka kwave kuzivikanwa uye kupa nzira nyowani dzekurapa varwere.Thalidomide inobatsirawo mukurapa bundu cachexia uye chemotherapy-inosanganisirwa kusvotwa uye kurutsa.Munguva yemishonga chaiyo yekurapa, zvakakosha kuongorora huwandu hwevanhu uye tumor subtypes dzinoshandathalidomidekurapwa uye kutsvaga biomarkers inofanotaura kushanda kwayo uye kuipa kwayo.