Chlorothiazide
Background
Chlorothiazide inhibitor yecarbonic anhydrase uye ine simba zvishoma pane acetazolamide.Mushonga uyu wakaratidzwa kudzivirira kudzoreredzwa kwesodium uye chloride ions.
Tsanangudzo
Chlorothiazide ine diuretic uye antihypertensive.(IC50=3.8 mM) Chinangwa: Zvimwe Chlorothiazide sodium (Diuril) mushonga unoshandiswa mukati mechipatara kana kuti kuzvishandisa iwe pachako kugadzirisa mvura yakawandisa ine chekuita ne congestive heart failure.Inoshandiswawo se antihypertensive.Kazhinji kazhinji inotorwa mufomu yepiritsi, inowanzotorwa nemuromo kamwe kana kaviri pazuva.Mugadziriro yeICU, chlorothiazide inopiwa kupatsanura murwere kuwedzera kune furosemide (Lasix).Kushanda mune imwe nzira pane furosemide, uye yakanyura mukati seyakagadziriswazve kuturika kunoitwa kuburikidza ne nasogastric chubhu (NG chubhu), iyo miviri mishonga inogona mumwe kune mumwe.
Clinical Muedzo
| Nhamba yeNCT | Sponsor | Condition | Zuva Rokutanga | Phase |
| NCT03574857 | Yunivhesiti yeVirginia | Kutadza Kwemoyo | Kutadza Kwemoyo Nekuderedzwa Ejection Fraction | Chikumi 2018 | Chikamu chechina |
| NCT02546583 | Yale University | National Heart, Lung, uye Ropa Institute (NHLBI) | Kutadza Kwemoyo | Nyamavhuvhu 2015 | Hazvigoneke |
| NCT02606253 | Vanderbilt University|Vanderbilt University Medical Center | Kutadza Kwemoyo | Kukadzi 2016 | Chikamu chechina |
| NCT00004360 | National Center for Research Resources (NCRR)|Northwestern University|Hofisi yeZvirwere Zvisingawanzo (ORD) | Chirwere cheshuga Insipidus, Nephrogenic | Gunyana 1995 |
|
| NCT00000484 | National Heart, Lung, uye Ropa Institute (NHLBI) | Cardiovascular Diseases| Zvirwere zveMwoyo|Hypertension | Vascular Diseases | Kubvumbi 1966 | Phase 3 |
Chimiro chemakemikari
Proposal18Quality Consistency Evaluation mapurojekiti akatenderwa4,uye6mapurojekiti ari pasi pekubvumidzwa.
Yepamberi yepasirese yemhando manejimendi system yakaisa hwaro hwakasimba hwekutengesa.
Kutariswa kwemhando yepamusoro kunofamba kuburikidza nehupenyu hwese kutenderera kwechigadzirwa kuti ive nechokwadi chemhando nekurapa.
Professional Regulatory Affairs timu inotsigira zvinodiwa zvemhando panguva yekushandisa uye kunyoreswa.
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DCS Control Room
