China Doxycycline Hyclate vagadziri uye vatengesi |CPF

Doxycycline Hyclate

Tsanangudzo Pfupi

Zita reAPI	Indication	Tsanangudzo	US DMF	EU DMF	CEP
Doxycycline Hyclate	Mishonga inorwisa mabhakitiriya	USP/EP	13771	√

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Background

Doxycycline hyclate mushonga unorwisa mabhakitiriya [1].

Doxycycline hyclate inobva kune tetracycline uye ine mabasa ekurwisa-kupisa uye antimicrobial.Doxycycline inhibits dengue virus replication in vitro nenzira inotsamira tembiricha.Iko IC50 kukosha ndeye 52.3μM pa37°C uye 26.7μM pa40°C.Inodzivirira hutachiona hwedengue kuburikidza nekudzivisa iyo NS2B-NS3 serine protease yehutachiona.60μM doxycycline inoderedza CPE yemasero ane utachiona hweDNEV2 [1].

Doxycycline inowanikwa kuva inhibitor yeMMP.Kurapa kweDoxycycline kunoderedza MMP-8 uye -9 mazinga uye kunodzivisa kutaura kwenyama MMP-2 uye MMP-9.Uyezve, kurapwa ne doxycycline kunoderedza zvakanyanya kuitika kwe intracranial aneurysms.Doxycycline yakave zvakare yakashumwa kuva anti-inflammatory agent inobva pakudzivisa kwayo matrix metalloproteinases.Mukuwedzera, doxycycline ine simba rekudzivirira marariya rine IC50 kukosha kwe320nM pa96h in vitro [2, 3].

References:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Inhibitory effect ye doxycycline against dengue virus replication in vitro.Arch Virol.2014 Kubvumbi159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Basa rematrix metalloproteinases (MMPs) uye MMP inhibitors pane intracranial aneurysms: chinyorwa chekuongorora.Med J Islam Repub Iran.2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro uye in vivo antimalarial efficacies ye optimized tetracyclines.Antimicrob Agents Chemother.2013 Jul;57(7):3131-6.

Tsanangudzo

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), mushonga unorwisa mabhakitiriya, inobata nemuromo uye yakafara-spectrum metalloproteinase (MMP) inhibitor [1].

Clinical Muedzo

Nhamba yeNCT	Sponsor	Condition	Zuva Rokutanga	Phase
NCT00246324	Louisiana State University Hutano Sayenzi Center Shreveport\|Biogen	Multiple Sclerosis	Zvita 2003	Chikamu chechina
NCT00910715	Yunivhesiti Medical Center Ljubljana	Erythema Chronicum Migrans	Chikumi 2009	Hazvigoneke
NCT00243893	Yunivhesiti yeCalifornia, San Francisco \| National Institute of Neurological Disorders uye Stroke (NINDS)	Aneurysms \| Arteriovenous Malformations	Chikunguru 2004	Phase 1
NCT00126399	CollaGenex Pharmaceuticals	Rosacea	Chikumi 2004	Phase 3
NCT01318356	Radboud University\|ZonMw: Iyo Netherlands Organisation for Health Research and Development	Q Fever \| Kuneta Syndrome, Chisingaperi \| Coxiella Infection	Kubvumbi 2011	Chikamu chechina
NCT00177333	Yunivhesiti yePittsburgh	Kubvisa nhumbu, kuitiswa\|Kurutsa	Gunyana 2005	Chikamu chechina
NCT00007735	US Department of Veterans Affairs\|Pfizer\|United States Dhipatimendi reDziviriro\|VA Hofisi Yekutsvagisa neKuvandudza	Persian Gulf Syndrome \| Mycoplasma Infections	Ndira 1999	Phase 3
NCT00351273	Yunivhesiti yeSouth Florida \| National Institute of Arthritis uye Musculoskeletal uye Skin Zvirwere (NIAMS)	Arthritis, Reactive \| Reiter Chirwere	Chivabvu 2006	Phase 3
NCT00469261	Careggi Hospital	Myocardial Infarction \| Kuruboshwe Ventricular Remodeling	Chivabvu 2007	Phase 2
NCT00547170	Yunivhesiti yePittsburgh \| Tu Du Hospital	Endometritis	Ndira 2007	Chikamu chechina
NCT01475708	Yunivhesiti Medical Center Ljubljana	Lyme Borreliosis	Chivabvu 2011
NCT01368341	Morten Lindbaek\|Norwegian Institute of Public Health\|Sorlandet Hospital HF\|Norwegian University of Life Sciences\|Yunivhesiti yeOslo	Erythema Migrans \| Erythema Chronicum Migrans \| Borreliosis \| Chirwere cheLyme \| Chirwere Chekutanga	Chikumi 2011	Chikamu chechina
NCT02538224	Islamic Azad University, Tehran	Chisingaperi Periodontitis	Chikunguru 2013	Chikamu 2 \| Phase 3
NCT00066027	Yunivhesiti yeNebraska \| National Institute of Dental uye Craniofacial Research (NIDCR)	Periodontitis	Chikumi 2002	Phase 3
NCT00376493	Hospital de Clinicas de Porto Alegre	Septic Abortion	Chivabvu 2006	Chikamu chechina
NCT03448731	Fundacion CRIS de Investigación ye Vencer el Cáncer\|Amgen\|Apices Soluciones SL	Skin Toxicity	Chivabvu 10, 2018	Phase 2
NCT00989742	Yunivhesiti yeNottingham	Lymphangioleiomyomatosis \| Tuberous Sclerosis	Chikunguru 2009	Chikamu chechina
NCT01438515	Horizon Health Network	Methicillin-inodzivirira Staphylococcus Aureus	Nyamavhuvhu 2008	Hazvigoneke
NCT02929121	The Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema \| Lymphatic Filariasis \| Filariasis	Ndira 15, 2019	Phase 3
NCT00952861	Odense University Hospital\|Kolding Sygehus\|Svendborg Hospital\|Fredericia Hospital\|Naestved Hospital\|Hillerod Hospital, Denmark\|Region Syddanmark\|Danmarks Lungeforening\|Danish National Research Foundation	Chirwere chePulmonary, Chronic obstructive	Gumiguru 2009	Chikamu chechina
NCT00138801	Sorlandet Hospital HF	Lyme Neuroborreliosis	Kurume 2004	Phase 3
NCT00942006	Yunivhesiti Medical Center Ljubljana	Kufungidzirwa Kwekutanga Lyme Neuroborreliosis	Chikunguru 2009	Hazvigoneke
NCT02713607	Yunivhesiti yeCalifornia, Davis	Acne Vulgaris	Kurume 2016	Chikamu 1 \| Chikamu 2
NCT00560703	Galderma	Blepharitis\|Meibomianitis\|Ziso Rakaoma	Mbudzi 2007	Phase 2
NCT01014260	Johns Hopkins University	Cardiovascular Disease	Gunyana 2010	Chikamu chechina
NCT00000938	National Institute of Allergy uye Infectious Diseases (NIAID)	Chirwere cheLyme		Phase 3
NCT01398072	University College, London\|Royal Yemahara Hampstead NHS Trust\|Yunivhesiti yeCambridge\|National Institute for Health Research, United Kingdom	Chronic Obstructive Pulmonary Disease (COPD).	Zvita 2011	Phase 3
NCT03479502	Vanderbilt University Medical Center \| Orthopedic Research uye Dzidzo Foundation	Adhesive Capsulitis \| Adhesive Capsulitis yeIsina kutaurwa	Ndira 5, 2018	Chikamu chechina
NCT02929134	The Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema \| Lymphatic Filariasis \| Filariasis	Kukadzi 16, 2018	Phase 3
NCT00480532	Oregon Health uye Science University	Kudzivirira pamuviri, Nemuromo	Chivabvu 2007	Hazvigoneke
NCT01594827	Johns Hopkins University \| Nyaya yeWestern Reserve University \| Cystic Fibrosis Foundation	Cystic Fibrosis	Gumiguru 2012	Phase 2
NCT01744093	Weill Medical College yeCornell University \| National Heart, Lung, uye Ropa Institute (NHLBI)	HIV \| Chronic Obstructive Pulmonary Disease (COPD)\| Emphysema	Chikunguru 17, 2014	Hazvigoneke
NCT03530319	National Taiwan University Hospital	Pneumonia, Mycoplasma	Mbudzi 10, 2018	Hazvigoneke
NCT04167085	Yunivhesiti yeCalifornia, Los Angeles	Epistaxis	Zvita 18, 2017	Chikamu chechina
NCT01411202	Ottawa Hospital Research Institute	Inokuvadza Pleural Effusion	Chikumi 2011	Phase 2
NCT01474590	Galderma	Mburwa	Mbudzi 2011	Phase 3
NCT00649571	Nhoroondo yeMylan Pharmaceuticals	Hutano	Chikunguru 2005	Phase 1
NCT02899000	Galderma Laboratories, LP	Acne Vulgaris	Chikunguru 29, 2016	Chikamu chechina
NCT00538967	Leiden University Medical Center	Aortic Aneurysm, Mudumbu	Chivabvu 2002	Phase 2
NCT00439400	Nhoroondo ye Alacrity Biosciences, Inc.	Ziso Rakaoma	Kukadzi 2007	Phase 2
NCT00917553	Thomas Gardner\|Penn State University\|Vadiki Diabetes Research Foundation\|Milton S. Hershey Medical Center	Chirwere cheshuga retinopathy	Chikunguru 2009	Phase 2
NCT00495313	CollaGenex Pharmaceuticals	Rosacea	Kurume 2007	Chikamu chechina
NCT01855360	Brigham uye Chipatara chevakadzi	Amyloidosis;Mwoyo (Kuratidza)\|Senile Cardiac Amyloidosis	Chikumi 2013	Chikamu 1 \| Chikamu 2
NCT00419848	Shahid Beheshti University of Medical Sayenzi	Mburwa	Nyamavhuvhu 2006	Phase 2
NCT03532464	University Hospital, Bordeaux\|USC EA 3671 Infections humanes à mycoplasmes uye chlamydiae	Chlamydia Trachomatis Infection \| Vaginal Infection \| Anal Infection	Chikunguru 1, 2018	Chikamu chechina
NCT02756403	Medstar Health Research Institute \| Sangano reKuronga Mhuri	First Trimester Kubvisa pamuviri	Kurume 2016	Hazvigoneke
NCT00353158	National Institute of Arthritis uye Musculoskeletal uye Skin Zvirwere (NIAMS)\|National Institutes of Health Clinical Center (CC)	Vazvipiri Vane Utano \| Fungal Infections\| Utachiona hweBhakitiriya	Chikunguru 11, 2006	Phase 1
NCT01317433	Institut Cancerology de l'Ouest	Colorectal Cancer Metastatic \| Ganda Toxicity	Zvita 2010	Phase 3
NCT01658995	Petra M. Casey\|Mayo Clinic	Kubuda ropa kwakabatana neESI	Gunyana 13, 2012	Phase 3
NCT03968562	State University yeNew York - Downstate Medical Center	Mikoko	Chivabvu 15, 2019	Phase 2
NCT02569437	Icahn Chikoro cheMishonga paGomo reSinai	Polyp yeNasal Sinus	Gunyana 2014	Phase 2
NCT01198509	NYU Langone Hutano\|National Institute of Arthritis uye Musculoskeletal uye Skin Zvirwere (NIAMS)\|Chirangaridzo Sloan Kettering Cancer Center	Rheumatoid Arthritis \| Psoriatic Arthritis \| Periodontal Disease	Ndira 2010	Hazvigoneke
NCT01163994	Yunivhesiti Medical Center Ljubljana	Multiple Erythema Migrans	Chikumi 2010	Hazvigoneke
NCT02388477	Milton S. Hershey Medical Center	Rotator Cuff Kukuvara		Hazvigoneke
NCT01010295	International Extranodal Lymphoma Study Group (IELSG)	Non-Hodgkin Lymphoma	Gunyana 2006	Phase 2
NCT00775918	Ranbaxy Laboratories Limited \| Ranbaxy Inc.	Hutano	Chikumi 2005	Hazvigoneke
NCT04050540	University of Washington\|Kenya Medical Research Institute\|Kenya National AIDS & STI Control Programme\|University of California, San Francisco\|National Institute of Allergy and Infectious Diseases (NIAID)	Utachiona hweHIV\|HIV+AIDS\|Neisseria Gonorrheae Infection\|Chlamydia Trachomatis Infection\|Syphilis Infection	Kukadzi 5, 2020	Chikamu chechina
NCT02562651	Russian Academy of Medical Sayenzi	Zvirwere zveVascular \| Cardiovascular Diseases \| Acute Myocardial Infarction	Kukadzi 2014	Chikamu 2 \| Phase 3
NCT00001101	National Institute of Allergy uye Infectious Diseases (NIAID)	Chirwere cheLyme		Phase 3
NCT00340691	National Institute of Allergy and Infectious Diseases (NIAID)\|National Institutes of Health Clinical Center (CC)	Mansonella Perstans Infection\|Mp Microfilaremia	Zvita 6, 2004	Phase 2
NCT01112059	Yunivhesiti yeAlabama kuBirmingham \| Cystic Fibrosis Foundation	Cystic Fibrosis	Mbudzi 2008	Hazvigoneke
NCT00652704	Par Pharmaceutical, Inc.\|Anapharm	Kuti usarudze Bioequivalence pasi peFed Conditions	Chikunguru 1999	Phase 1
NCT01783860	Tehran Yunivhesiti yeMedical Sayenzi	Posterior Blepharitis	Ndira 2013	Phase 2
NCT02564471	State University yeNew York - Upstate Medical University\|Walter Reed Army Institute of Research (WRAIR)\|Kansas State University	Chimbwamupengo	Kubvumbi 2016	Chikamu chechina
NCT04206631	Indonesia University	Acne Vulgaris	Kubvumbi 1, 2015	Phase 1
NCT03956446	University Medical Center Ljubljana\|Yunivhesiti yeLjubljana Chikoro cheMishonga, Slovenia	Chikwekwe Borne Encephalitis	Gunyana 1, 2014	Hazvigoneke
NCT03960411	Felix Chikita Fredy, MD\|National Cardiovascular Center Harapan Kita Hospital Indonesia\|Indonesia University	ST Elevation Myocardial Infarction\|Anterior Wall Myocardial Infarction\|Kutadza Kwemoyo\|Kugadziridza, Ventricular	Chivabvu 25, 2019	Phase 3
NCT00322465	National Institute of Allergy uye Infectious Diseases (NIAID)	Urethritis	Mbudzi 2006	Phase 2
NCT01375491	University of California, San Diego\|Ruth L. Kirschstein National Research Service Award\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Center for Research Resources (NCRR)	Type 2 Diabetes\|Kufutisa	Gumiguru 2009	Chikamu chechina
NCT03478436	Medical University yeVienna \| Dr.Iyo kambani Reddy's Laboratories Limited	Rosacea	Chikunguru 2016	Phase 1
NCT01207739	Radboud University\|Sint Maartenskliniek\|ZonMw: Sangano reNetherlands reKutsvagisa Hutano neBudiriro	Chirwere cheLyme \| Borrelia Infection	Gunyana 2010	Chikamu chechina
NCT00939562	Pfizer	Utachiona hweBhakitiriya	Mbudzi 2008	Chikamu chechina
NCT03608774	National Institute of Allergy uye Infectious Diseases (NIAID)	Anal Chlamydia Infection	Chikumi 26, 2018	Chikamu chechina
NCT02281643	Kwame Nkrumah Yunivhesiti yeScience uye Technology \| Yunivhesiti yeBonn \| Heinrich-Heine University, Duesseldorf	Mansonella Perstans Infection\|Buruli Ulcer\|Tuberculosis\|Co-infection	Gumiguru 2014	Phase 2
NCT00066066	Iyo Forsyth Institute \| National Institute of Dental uye Craniofacial Research (NIDCR)	Periodontitis \| Zvirwere zvePeriodontal	Chikunguru 2003	Phase 2
NCT01798225	Medical University yeSouth Carolina \| National Center for Research Resources (NCRR)	Periodontal Disease \| Type 2 Diabetes Mellitus	Zvita 2007	Chikamu chechina
NCT00612573	Warner Chilcott	Acne Vulgaris	Kukadzi 2008	Phase 2
NCT01631617	National Institute of Arthritis uye Musculoskeletal uye Skin Zvirwere (NIAMS)\|National Institutes of Health Clinical Center (CC)	Eczema\|Dermatitis\|Zvirwere zveGanda, Genetic\|Dermatitis, Atopic\|Zvirwere Zveganda	Gunyana 18, 2012	Phase 2
NCT03173053	Radboud University\|ZonMw: The Netherlands Organisation for Health Research and Development\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|Aalborg University Hospital\|Rigshospitalet, Denmark	Staphylococcus Aureus \| Motility Disorder	Kukadzi 8, 2018	Hazvigoneke
NCT00715858	McMaster University \| The Physicians' Services Incorporated Foundation	Chirwere cheAlzheimer	Chivabvu 2008	Phase 3
NCT03584919	Yunivhesiti Medical Center Ljubljana	Erythema Chronicum Migrans	Chikumi 1, 2006	Hazvigoneke
NCT01469585	Yunivhesiti yeHawaii\|Charles Drew University yeMishonga neSainzi\|Meharry Medical College	Breakthrough Bleeding	Mbudzi 2011	Hazvigoneke
NCT02759120	Weill Medical College yeCornell University\|Duke Clinical Research Institute\|Yunivhesiti yeChicago\|Yunivhesiti yeWashington\|Yunivhesiti yePittsburgh\|National Heart, Lung, uye Ropa Institute (NHLBI)	Idiopathic Pulmonary Fibrosis	Kurume 22, 2017	Phase 3
NCT02735837	Amirhossein Farahmand\|Islamic Azad University, Tehran	Diabetes Mellitus With Periodontal Disease	Ndira 2015	Chikamu 2 \| Phase 3
NCT03655197	Yunivhesiti yeCalifornia, Davis	Rosacea \| Ocular Rosacea \| Cutaneous Rosacea	Mbudzi 2, 2017	Early Phase 1
NCT01188954	Northwell Health	Seroma	Ndira 2010	Hazvigoneke
NCT00388778	Shahid Beheshti University of Medical Sayenzi	Acne\|Kuzvimba	Gumiguru 2005	Chikamu 2 \| Phase 3
NCT01087476	Metropolitan Autonomous University \| Instituto Nacional yeCancerology yeMexico	Mucositis	Chivabvu 2010	Phase 2
NCT02174757	CD Pharma India Pvt.Ltd.\|Sree Mookambika Institute of Dental Sciences	Chisingaperi Periodontitis	Nyamavhuvhu 2014	Phase 3
NCT03911440	National Taiwan University Hospital	Atypical Pneumonia	Mbudzi 10, 2018	Hazvigoneke
NCT02553083	Rabin Medical Center	Utachiona hweBhakitiriya nekuda kweHelicobacter Pylori (H. Pylori)	Gumiguru 22, 2015	Chikamu chechina
NCT04234945	Ahmadu Bello University Teaching Hospital	Kusabereka, Mukadzi \| Pelvic Inflammatory Disease	Ndira 13, 2020	Hazvigoneke
NCT00892281	Galderma Laboratories, LP	Rosacea	Kubvumbi 2009	Chikamu chechina
NCT02913118	Qingfeng Pharmaceutical Group	Community Yakawana Pneumonia	Chikunguru 2016	Chikamu chechina
NCT04153604	Methodist Health System	Cirrhosis \| Kungoerekana kwaita Bhakitiriya Peritonitis	Mbudzi 4, 2019
NCT03153267	University Medical Center Ljubljana\|Yunivhesiti yeLjubljana Chikoro cheMishonga, Slovenia	Erythema Chronicum Migrans	Chikumi 1, 2017	Hazvigoneke
NCT03116659	James J. Peters Veterans Affairs Medical Center	Lymphoma, T-Cell, Cutaneous	Kukadzi 1, 2018	Early Phase 1
NCT03401372	Jian Li\|Peking University First Hospital\|Chinese PLA General Hospital\|Beijing Chao Yang Hospital\|West China Hospital Yakabatana neSichuan University\|Tongji Hospital Yakabatana neTongji Medical College yeHUST\|Union Hospital Yakabatana neTongji Medical College yeHUST\|Shanghai Changzheng Hospital\| Nanfang Hospital yeSouthern Medical University \| Peking Union Medical College Hospital	Amyloidosis;Systemic	Kubvumbi 21, 2018	Hazvigoneke
NCT01380496	Par Pharmaceutical, Inc.\|Anapharm	Kuti usarudze Bioequivalence pasi peFed Conditions	Mbudzi 1999	Phase 1
NCT03083197	University of Oxford\|Shoklo Malaria Research Unit\|Chiangrai Prachanukroh Hospital	Kukwesha Typhus	Gumiguru 15, 2017	Chikamu chechina
NCT00237016	Medical Corps, Israel Defence Force	Kudzokorora Fever, Tick-Borne\|Jarisch Herxheimer Reaction	Kubvumbi 2002	Chikamu 2 \| Phase 3
NCT01308619	Galderma Laboratories, LP	Rosacea	Kubvumbi 2011	Chikamu chechina
NCT01198912	Chipatara cheYunivhesiti, Ghent	Chronic Rhinosinusitis \| Nasal Polyps	Mbudzi 22, 2011	Phase 2
NCT02016365	Umeå University	Transthyretin Amyloidosis \| Cardiomyopathy	Kukadzi 2012	Phase 2
NCT00783523	Yunivhesiti yeCalifornia, San Francisco	Arteriovenous Malformations\|Cavernous Angiomas\|Brain Aneurysms	Kurume 2008	Phase 1
NCT03337932	Yunivhesiti Medical Center Ljubljana	Erythema Chronicum Migrans	Ndira 1, 2018	Hazvigoneke
NCT00568711	Dong-Min Kim \| Chosun University Hospital	Kukwesha Typhus	Gunyana 2006	Hazvigoneke
NCT01874860	Yunivhesiti yeLouisville \| James Graham Brown Cancer Center	Colorectal Cancer \| Musoro uye Mutsipa Kenza	Nyamavhuvhu 2013	Phase 2
NCT01171859	IRCCS Policlinico S. Matteo	Transthyretin Amyloidosis	Chikunguru 2010	Phase 2
NCT01653522	Iyo Cleveland Clinic	Migraine Disorders\|Musoro, Migraine\|Migraine\|Migraine Headache\|Migraine With Aura\|Migraine Pasina Aura\|Kurwadzisa Musoro, Primary	Chikunguru 2012	Hazvigoneke
NCT01820910	International Extranodal Lymphoma Study Group (IELSG)	Marginal Zone Lymphoma yeOcular Adnexal	Kurume 2013	Phase 2
NCT01323101	Yunivhesiti yeSouthern California	Cystic Fibrosis	Kubvumbi 2008	Chikamu chechina
NCT00829764	Teva Pharmaceuticals USA	Hutano	Gumiguru 2006	Phase 1
NCT01668498	AIO-Mudzidzi-gGmbH	Ras-wildtype Colorectal Cancer	Chivabvu 2011	Phase 2
NCT01030666	Peter Eickholz\|Heidelberg University\|Dr.August Wolff GmbH & Co. KG Arzneimittel\|Gaba International AG\|Goethe University	Periodontitis	Kubvumbi 2007	Chikamu chechina
NCT00012688	US Department of Veterans Affairs\|Colgate-Periogard-Dentsply\|VA Hofisi Yekutsvagisa neBudiriro	Chirwere cheshuga mellitus \| Yakashata Glycemic Control \| Peridontal Chirwere		Hazvigoneke
NCT01885910	Derm Research, PLLC \| WFH MEDICAL, LLC	Acne Vulgaris	Chikunguru 2013	Chikamu chechina
NCT02328469	University Medical Center Ljubljana\|Slovenian Research Agency\|Yunivhesiti yeLjubljana Chikoro cheMishonga, Slovenia\|Harvard University	Aseptic Meningitis	Chikumi 2014
NCT00355602	Yunivhesiti yeDundee \| Tenovus Scotland	Colitis, Zvironda	Chikunguru 2006	Hazvigoneke
NCT02606032	Hamilton Hutano Sayenzi Corporation \| Hamilton Academic Health Sayenzi Sangano	Ulcerative Colitis	Chivabvu 2016	Phase 2
NCT01465802	Pfizer	Non Diki Cell Lung Cancer (NSCLC)	Zvita 26, 2011	Phase 2
NCT02623959	MD Anderson Cancer Center	Zvirwere zveCancer \| Zvakaipa Pleural Effusions	Kubvumbi 27, 2016	Chikamu chechina
NCT03481972	IRCCS Policlinico S. Matteo	TTR Mwoyo Amyloidosis	Kubvumbi 11, 2018	Phase 3
NCT00428818	Yunivhesiti yeTexas Southwestern Medical Center	Utachiona	Nyamavhuvhu 2005	Hazvigoneke
NCT01935622	Virginia Commonwealth University	Non-ischemic Cardiomyopathy\|Systolic Heart Failure (NYHA II-III)	Chikunguru 2012	Phase 2
NCT01886560	Sun Yat-sen University	Kupisa Kwemaziso	Gunyana 2013	Chikamu 2 \| Phase 3
NCT04239755	Damanhour University \| Tanta University	Traumatic Brain Injury	Zvita 15, 2019	Chikamu chechina
NCT02204254	Center Hospitaler Universitaire de Nice	Rosacea	Kurume 2014	Hazvigoneke
NCT00837213	Stiefel, kambani yeGSK\|GlaxoSmithKline	Mburwa	Nyamavhuvhu 2007	Chikamu chechina
NCT03115177	Rush University Medical Center	Osteoarthritis	Mbudzi 2015	Hazvigoneke
NCT03618108	Cadrock Pty. Ltd.\|Center for Digestive Diseases, Australia	Chirwere cheMwoyo cheCoronary \| Chlamydophila Pneumoniae Infections	Kubvumbi 4, 2018	Phase 2
NCT03435952	MD Anderson Cancer Center\|BioMed Valley Discoveries, Inc\|Merck Sharp & Dohme Corp.	Malignant Neoplasm yezamu Sites\|Akaipa Neoplasms yeLip Oral Cavity uye Pharynx\|Akaipa Neoplasms yeMurume Genital Organs\|Akaipa Neoplasms yeMesothelial uye Soft Tissue\|Akaipa Neoplasms eKufemerwa uye Intrathoracic Organs\|Nharo Neoplasms yeThrocrine Upfu uye Dzimwe	Chikunguru 10, 2018	Phase 1
NCT01867294	Yedzidzo uye Yenharaunda Cancer Research United \| National Cancer Institute (NCI)	Yepamusoro Malignant Neoplasm \| Dermatologic Complication	Nyamavhuvhu 31, 2012	Phase 2
NCT01677286	Boston University	Amyloidosis	Chikunguru 2012	Phase 2
NCT00511875	Thomas Gardner\|Vadiki Diabetes Research Foundation\|Milton S. Hershey Medical Center	Chirwere cheshuga retinopathy	Chikunguru 2008	Phase 2
NCT04108897	Johns Hopkins University	Rosacea	Gunyana 17, 2019	Early Phase 1
NCT00631501	Kaunas University of Medicine \| Chipatara cheYunivhesiti, Linkoeping	Lateral Epicondylalgia (Tennis Elbow)		Hazvigoneke
NCT02203682	Sun Yat-sen University	Graves Ophthalmopathy\| Zvirwere zveMakuva\| Zvirwere zveZiso \| Zvirwere zveThyroid \| Endocrine System Zvirwere	Chikunguru 2014	Phase 2
NCT02005653	Indian Council of Medical Research	Filarial;Infestation	Kukadzi 2009	Chikamu chechina
NCT03585140	Centro Dermatológico Dr. Ladislao de la Pascua	Acne Vulgaris \| Kugadziriswa Kwekudya	Ndira 1, 2016	Hazvigoneke
NCT02147262	University Medical Center Ljubljana\|Yunivhesiti yeLjubljana Chikoro cheMishonga, Slovenia\|Medical University yeVienna\|Harvard University	Chronic Atrophic Acrodermatitis	Chikunguru 2013	Hazvigoneke
NCT02220751	Yunivhesiti yeSao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontitis \| Type 2 Diabetes Mellitus	Kurume 2009	Phase 3
NCT01825408	Yunivhesiti yeNorth Carolina, Chapel Hill	Sinusitis	Kukadzi 2013	Chikamu chechina
NCT02884713	King Faisal Specialist Hospital & Research Center	GASTRITIS	Chikumi 2013	Hazvigoneke
NCT02726646	Yunivhesiti yeCampinas, Brazil\|Pontificia Universidade Catolica de Sao Paulo	Chisingaperi Periodontitis	Chikumi 2015	Phase 2
NCT00883818	Samsung Medical Center	Overactive Dundira	Ndira 2007	Chikamu chechina
NCT00829790	Teva Pharmaceuticals USA	Hutano	Gumiguru 2006	Phase 1
NCT01949233	Yunivhesiti yeOxford \| Oxford University Hospitals NHS Trust	Marfan Syndrome	Gumiguru 2013	Phase 2
NCT01518192	University Medical Center Ljubljana\|Slovenian Research Agency	Erythema Migrans \| Post-Lyme Chirwere Zviratidzo	Chikumi 2006	Chikamu chechina
NCT02845024	Islamic Azad University, Tehran	Diabetes Mellitus With Periodontal Disease	Gunyana 2014	Hazvigoneke
NCT01879930	University Hospital Inselspital, Berne	Chronic Pelvic Pain Syndrome\|Dundira Pain Syndrome	Mbudzi 2012	Chikamu chechina
NCT00041977	CollaGenex Pharmaceuticals	Acne Rosacea	Chikumi 2002	Phase 3
NCT02341209	Rochester General Hospital	Cutaneous T-cell Lymphoma \| Mycosis Fungoides \| Sezary Syndrome	Kukadzi 6, 2018	Phase 2
NCT00002872	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|North Central Cancer Treatment Boka	Metastatic Cancer	Mbudzi 1996	Phase 3
NCT03162497	Medical University yeVienna	Dry Eye Syndromes\|Meibomian Gland Dysfunction	Ndira 8, 2018	Chikamu chechina
NCT01418742	Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH\|ClinAssess GmbH	Colorectal Carcinoma	Nyamavhuvhu 2011	Phase 2
NCT00980148	National Institute of Allergy uye Infectious Diseases (NIAID)	Chlamydial Infection	Zvita 2009	Phase 3
NCT03342456	The Third Xiangya Hospital yeCentral South University\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm.Ind. Co., Ltd.	Duodenal Ulcer Nokuda kweHelicobacter Pylori	Zvita 13, 2017	Chikamu chechina
NCT04310930	Yunivhesiti yeQueensland\|Dhipatimendi reHurumende yeAustralia yehutano\|Chipatara chevana Foundation\|Cystic Fibrosis Foundation\|Newcastle University\|Griffith University\|Erasmus Medical Center\|Monash University\|University of Copenhagen\|Hôpital Cochin\|South Australian Hutano uye Medical Research Institute\|Yunivhesiti yeMelbourne\|James Cook University, Queensland, Australia\|Murdoch Childrens Research Institute	Chirwere chePulmonary nekuda kweMycobacteria (Kuongororwa)	Kurume 2020	Chikamu 2 \| Phase 3
NCT03709459	Kirby Institute\|South Australia Hutano uye Medical Research Institute\|Monash University	Kudzivirira STIs	Zvita 17, 2019
NCT04067011	Emergent BioSolutions\|Biomedical Advanced Research and Development Authority	Chigwadara	Nyamavhuvhu 12, 2019	Phase 2
NCT02844634	British Columbia Center for Disease Control	HIV\|Syphilis	Chivabvu 15, 2018	Chikamu chechina
NCT00647959	Nhoroondo yeMylan Pharmaceuticals	Hutano	Kurume 2006	Phase 1
NCT00170222	Medical Center Alkmaar	Chronic Obstructive Pulmonary Disease	Chikunguru 2002	Chikamu chechina
NCT03075891	Galderma	Rosacea	Chikunguru 5, 2017	Chikamu chechina
NCT00031499	National Institute of Allergy uye Infectious Diseases (NIAID)	Syphilis	June 2000	Phase 3
NCT01205464	Linkoeping University	Kuneta	Kukadzi 2005	Hazvigoneke
NCT01301586	Nhoroondo ye Nexgen Dermatologics, Inc.	ACNE VULGARIS	Mbudzi 2010	Chikamu 1 \| Chikamu 2
NCT02305940	Imperial College London	Chirwere Chisingaperi chePulmonary Disease (COPD)	Chikunguru 2014	Phase 3
NCT00351182	Dong-Min Kim \| Chosun University Hospital	Kukwesha Typhus	Gunyana 2005	Phase 3
NCT03334682	Nantes University Hospital	Acne Vulgaris	Ndira 31, 2018	Phase 3
NCT01788215	Yunivhesiti yeRochester	Polycystic Ovarian Syndrome (PCOS)\|Kusakwana Kwekuenda Kumwedzi \| Androgen Yakawandisa	Mbudzi 2010	Phase 3
NCT03076281	Sidney Kimmel Cancer Center paThomas Jefferson University \| Thomas Jefferson University	Larynx\|LIP\|Oral Cavity\|Pharynx	Kubvumbi 3, 2017	Phase 2
NCT00439166	Hamilton Health Sciences Corporation \| The Physicians' Services Incorporated Foundation\|McMaster University	Chirwere cheAlzheimer	Kukadzi 2007	Phase 3
NCT02463942	University Medical Center Ljubljana\|Yunivhesiti yeLjubljana Chikoro cheMishonga, Slovenia	Chikwekwe Encephalitis	Gunyana 2014	Hazvigoneke
NCT00803842	Northwestern University	Non Diki Cell Lung Cancer	Gumiguru 2008	Hazvigoneke
NCT02086591	Yunivhesiti yeRochester	Munhu mukuru Diffuse Large B-Cell Lymphoma\|Mantle Cell Lymphoma Recurrent\|Lymphoma, Follicular\|Marginal Zone B-Cell Lymphoma\|Malignant Lymphoma - Lymphoplasmacytic\|Waldenstrom Macroglobulinemia\|Small Lymphocytic Lymphoma\|Chronic Lymphocytic Leukemia-Cell Lymphoma (CLL)	Kurume 2014	Phase 2
NCT03980223	Yunivhesiti yeCalifornia, San Francisco \| Yunivhesiti yeWashington \| National Institute of Allergy uye Infectious Diseases (NIAID)\|Mayne Pharma International Pty Ltd\|San Francisco Dhipatimendi reHutano Hwevanhu.	Gonorrhea\|Chlamydia\|Syphilis	Mbudzi 26, 2019	Chikamu chechina
NCT00355459	Yunivhesiti yeTexas Southwestern Medical Center	Dry Eye Syndrome	Nyamavhuvhu 2005	Hazvigoneke
NCT01254799	Omar Mamdouh Shaaban\|Assiut University	Uterine Hemorrhage	Ndira 2008	Phase 3
NCT01547325	NanoSHIFT LLC\|United States Dhipatimendi reDziviriro	Dehisced Kuvhiya Maronda	Chivabvu 2012	Hazvigoneke
NCT00653380	Par Pharmaceutical, Inc.\|Anapharm	Kuona Bioequivalence Pasi peKutsanya Mamiriro	Gunyana 1999	Phase 1
NCT00635609	Warner Chilcott	Acne Vulgaris	Kurume 2008	Chikamu chechina
NCT03765931	Institut de Recherche pour le Developpement	Kupindwa nechando	Chikunguru 2016	Chikamu chechina
NCT01160640	Harold Wiesenfeld \| National Institute of Allergy uye Infectious Diseases (NIAID) \| Yunivhesiti yePittsburgh	Pelvic Inflammatory Disease	Mbudzi 2010	Phase 2
NCT01756833	Yunivhesiti yeMaryland, Baltimore \| National Institute on Aging (NIA)	Aneurysm	Chivabvu 2013	Phase 2
NCT00688064	Galderma	Yakanyanya Acne Vulgaris	Nyamavhuvhu 2008	Phase 3
NCT01320033	Galderma	Acne Vulgaris	Kurume 29, 2011	Phase 2
NCT03397004	St. Michael's Hospital, Toronto\|Barrow Neurological Institute\|Duke University\|Feinstein Institute for Medical Research\|Yunivhesiti yePittsburgh\|Sunnybrook Health Sciences Center	Hereditary Hemorrhagic Telangiectasia (HHT)	Gunyana 12, 2018	Phase 2
NCT01635530	Turku University Hospital	Lyme Neuroborreliosis	Nyamavhuvhu 2012	Chikamu chechina
NCT03727620	Mohammed V Souissi University	Aggressive Periodontitis	Ndira 6, 2014	Chikamu 1 \| Chikamu 2
NCT02688738	Rothman Institute Orthopedics	Propionibacterium	Kurume 2015	Hazvigoneke
NCT00358462	Yunivhesiti yeWashington \| National Institute of Allergy uye Infectious Diseases (NIAID)	Urethritis	Ndira 2007	Phase 3
NCT02864550	British Columbia Center for Disease Control	Syphilis\|Zvirwere Zvepabonde	Nyamavhuvhu 15, 2019	Chikamu chechina
NCT01595594	Yunivhesiti yeSao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontal Disease \| Type 2 Diabetes	Kurume 2010	Phase 3
NCT00964834	PharmAthene, Inc.\|National Institutes of Health (NIH)\|Medarex\|Quintiles, Inc.\|Department of Health and Human Services	Chigwadara	Chikunguru 2009	Phase 1
NCT01809444	Sun Yat-sen University	Thyroid Associated Opthalmopathies	Mbudzi 2012	Chikamu 2 \| Phase 3
NCT01590082	MD Anderson Cancer Center \| National Institutes of Health (NIH) \| National Cancer Institute (NCI)	Melanoma	Mbudzi 2012	Chikamu 1 \| Chikamu 2
NCT00207584	Centers for Disease Control and Prevention	Mycoplasma Pneumoniae	Ndira 1994	Hazvigoneke
NCT00775177	Ranbaxy Laboratories Limited \| Ranbaxy Inc.	Hutano	Chikumi 2005	Hazvigoneke
NCT03462329	Yunivhesiti Medical Center Ljubljana	Erythema Migrans	Chikumi 1, 2018	Hazvigoneke
NCT00000403	Indiana University \| National Institute of Arthritis uye Musculoskeletal uye Skin Zvirwere (NIAMS) \| National Institute on Aging (NIA)	Osteoarthritis	Gunyana 1996	Phase 3
NCT03508232	Yunivhesiti yeAlberta \| Royal Alexandra Hospital	ST Segment Elevation Myocardial Infarction\|Kutadza Kwemoyo	Ndira 6, 2020	Phase 2
NCT02553473	Sorlandet Hospital HF	Neuroborreliosis, Borrelia Burgdorferi	Gumiguru 2015	Phase 3
NCT02207556	Medical College yeWisconsin	Primary Systemic Amyloidosis	Gumiguru 1, 2014	Phase 2
NCT01783106	Royal Liverpool University Hospital \| National Association yeColitis uye Chirwere cheCrohn \| National Institute for Health Research, United Kingdom	Chirwere cheCrohn	Kukadzi 1, 2014	Phase 2
NCT00353743	Hospital de Clinicas de Porto Alegre	Kubvisa pamuviri, Septic	Chivabvu 2006	Hazvigoneke
NCT01727973	Sun Yat-sen University	Graves Ophthalmopathy\| Zvirwere zveMakuva\| Zvirwere zveZiso \| Zvirwere zveThyroid \| Endocrine System Zvirwere	Gumiguru 2012	Chikamu 1 \| Chikamu 2
NCT00857038	Medical Center Alkmaar\|Leiden University Medical Center\|Yunivhesiti yeAmsterdam	Chisingaperi Chinodzivirira Pulmonary Chirwere\|Kuzvimba\|Pulmonary Emphysema	Kubvumbi 2009	Chikamu chechina
NCT02774993	National University Hospital, Singapore\|Tan Tock Seng Hospital\|National University, Singapore\|A*Star	Tibhii	Gunyana 2015	Phase 2
NCT03474458	IRCCS Policlinico S. Matteo	Cardiac AL Amyloidosis	Kukadzi 11, 2019	Chikamu 2 \| Phase 3
NCT02874430	Sidney Kimmel Cancer Center paThomas Jefferson University \| Thomas Jefferson University	Breast Carcinoma\|Endometrial Clear Cell Adenocarcinoma\|Endometrial Serous Adenocarcinoma\|Uterine Corpus Cancer\|Uterine Corpus Carcinosarcoma	Chikumi 8, 2016	Phase 2
NCT00016835	Yunivhesiti yeMichigan \| National Institute of Dental uye Craniofacial Research (NIDCR)	Periodontal Chirwere \| Chirwere cheshuga mellitus, Rudzi rwechipiri	Gumiguru 17, 2001	Phase 2
NCT00064766	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Endometrial Bleeding \| Periodontal Disease	Kukadzi 2003	Chikamu chechina
NCT00803452	Yunivhesiti yeLouisville	Blepharitis	Chikunguru 2008	Chikamu chechina
NCT01434173	Bayer\|RTI Health Solutions	Kukuvara Kwechiropa Kunokonzerwa Nezvinodhaka	Chikunguru 2001
NCT00126204	Barnes-Jewish Hospital	Aortic Aneurysm	Kurume 2004	Hazvigoneke
NCT01917721	Hawaii Pacific Health	Chirwere cheKawasaki \| Coronary Aneurysm	Gumiguru 2013	Phase 2
NCT02775695	Medical College yeWisconsin	Resectable Pancreatic Cancer	Kubvumbi 3, 2017	Phase 2
NCT03824340	Aljazeera Hospital	Kushaya mbereko	Ndira 30, 2019	Hazvigoneke
NCT01847976	Ottawa Hospital Research Institute \| Canadian Breast Cancer Foundation	Marwadzo	Nyamavhuvhu 2013	Phase 2
NCT02850913	Makerere University \| Yunivhesiti yeOxford	Kubatwa nepfari	Gunyana 5, 2016	Phase 2
NCT00764361	NanoSHIFT LLC	Diabetic Foot Ulcer	Ndira 2009	Phase 2
NCT02036528	Nhoroondo ye Royer Biomedical, Inc.	Diabetic Foot Ulcers	Ndira 2014	Chikamu 1 \| Chikamu 2
NCT01661985	Ostergotland County Council, Sweden\|Statens Serum Institut	Urethritis\|Cervicitis\|Genital Mycoplasma Infection\|Chlamydia Trachomatis	Kukadzi 2010	Chikamu chechina
NCT01380483	Par Pharmaceutical, Inc.\|Anapharm	Kuona Bioequivalence Pasi peKutsanya Mamiriro	Ndira 2000	Phase 1
NCT00648180	Nhoroondo yeMylan Pharmaceuticals	Hutano	Chikunguru 2005	Phase 1
NCT01426269	Galderma Laboratories, LP	Rosacea	Gunyana 2011	Chikamu chechina
NCT02753426	Yunivhesiti yeCalifornia, San Francisco	Chirwere cheKidney Chisingaperi \| Cardiorenal Syndrome	Kubvumbi 2016	Phase 1
NCT02583282	Postgraduate Institute of Medical Dzidzo uye Tsvagiridzo	Inokuvadza Pleural Effusion	Nyamavhuvhu 1, 2015	Hazvigoneke
NCT02927496	The Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema \| Lymphatic Filariasis \| Filariasis	Chikumi 19, 2018	Phase 3
NCT00652795	Par Pharmaceutical, Inc.\|Anapharm	Kuona Bioequivalence Pasi peKutsanya Mamiriro	Chikunguru 2004	Phase 1
NCT03956212	University Medical Center Ljubljana\|Yunivhesiti yeLjubljana Chikoro cheMishonga, Slovenia	Erythema Migrans	Chikumi 1, 2017	Hazvigoneke
NCT00855595	Bayer	Papulopustular Rosacea	Kukadzi 2009	Chikamu chechina
NCT03457636	Derm Research, PLLC	Mburwa	Kurume 19, 2018	Chikamu chechina
NCT02894268	Sir Run Run Shaw Hospital	Helicobacter Pylori Infection	Kukadzi 2016	Chikamu chechina
NCT03465774	MD Anderson Cancer Center \| National Cancer Institute (NCI)	Inokuvadza Pleural Effusion	Kurume 8, 2018	Early Phase 1