Pitavastatin Calcium
| 匹伐他汀钙 | Pitavastatin | 147526-32-7 | Mumba |
| PI-5 | 3800-06-4 | Mumba | |
| PI-6 | 145516-11-4 | Mumba | |
| PI-7 | 121660-11-5 | Mumba |
Tsanangudzo
Pitavastatin Calcium (NK-104 hemicalcium) ine simba hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor.Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis kubva kuacetic acid ine IC50 ye5.8 nM muHepG2 masero.Pitavastatin Calcium inoshanda hepatocyte yakaderera-density lipoprotein-cholesterol (LDL-C) receptor inducer.Anti-gomarara basa.
Background
Pitavastatin Calcium inokwikwidza inhibitor ye enzyme HMGCR (HMG-CoA reductase) inoguma nekuderedza kweLDL cholesterol synthesis.Zvimwe zvidzidzo zvinoratidza kuti pitavastatin inogona kudzvinyirira kugadzirwa kweokisijeni mumasero endothelial nekudzivisa NADPH oxidase.Pamusoro pezvo, pitavastatin inoderedza kutaura kweNOS mRNA uku ichiwedzera NO inotsamira mhinduro inokurudzirwa neacetylcholine uye calcium ionophore, A23187.Uyezve, pitavastatin inhibits up-regulation of conductance calcium-activated potassium channels nekuderedza cholesterol mumasero.
Storage
4°C, kudzivirira kubva kuchiedza
*In solvent : -80°C, mwedzi mitanhatu;-20°C, mwedzi 1 (dzivirira kubva kuchiedza)
Chimiro chemakemikari
Related Biological Data
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