Captopril
Tsanangudzo
Captopril (SQ-14534) ine simba, inokwikwidza inhibitor yeangiotensin-inoshandura enzyme (ACE).
In Vitro
Captopril (SQ-14534) yakaratidzwa kuva nehutano hwakafanana nekufa kune avo vane diuretics uye beta-blockers muvarwere vane hypertensive.Captopril (SQ-14534) yakaratidza kunonoka kufambira mberi kwechirwere cheshuga nephropathy, uye enalapril nelisinopril kudzivirira kukura kwenephropathy muvarwere venormoalbuminuric vane chirwere cheshuga[1].A equimolar ratio ye cis and trans states of Captopril (SQ-14534) iripo mumhinduro uye kuti enzyme inosarudza chete trans state ye inhibitor iyo inopa architectural uye stereoelectronic complementarity ne substrate inosunga groove [2].
MCE haina kuzvimiririra yakasimbisa chokwadi chenzira idzi.Ndedzekureva chete.
Clinical Muedzo
| Nhamba yeNCT | Sponsor | Condition | Zuva Rokutanga | Phase |
| NCT03179163 | Penn State University | National Heart, Lung, uye Ropa Institute (NHLBI) | Hypertension, yakakosha | Chikunguru 20, 2016 | Chikamu 1 | Chikamu 2 |
| NCT03660293 | Tanta University | Chirwere cheshuga mellitus, Type 1 | Kubvumbi 1, 2017 | Hazvigoneke |
| NCT03147092 | Centro Neurológico de Pesquisa e Reabiitação, Brazil | Hypertension | Kushushikana Kweropa | Kukadzi 1, 2018 | Early Phase 1 |
| NCT00252317 | Rigshospitalet, Denmark | Aortic Stenosis | Mbudzi 2005 | Chikamu chechina |
| NCT02217852 | Chipatara cheWest China | Hypertension | Nyamavhuvhu 2014 | Chikamu chechina |
| NCT01626469 | Brigham uye Chipatara chevakadzi | Type 2 Diabetes Mellitus | Chivabvu 2012 | Chikamu 1 | Chikamu 2 |
| NCT00391846 | AstraZeneca | Kutadza Kwemoyo|Kusashanda zvakanaka kweVentricular, Kuruboshwe | Gumiguru 2006 | Chikamu chechina |
| NCT00240656 | Hebei Medical University | Hypertension, Pulmonary | Gumiguru 2005 | Phase 1 |
| NCT00086723 | Northwestern University | National Cancer Institute (NCI) | Zvisina Kutaurwa Adult Solid Tumor, Protocol Specific | Chikunguru 2003 | Chikamu 1 | Chikamu 2 |
| NCT00663949 | Shiraz University of Medical Sayenzi | Chirwere cheshuga nephropathy | Kukadzi 2006 | Chikamu 2 | Phase 3 |
| NCT01437371 | Chipatara cheYunivhesiti, Clermont-Ferrand|Servier|LivaNova | Kutadza Kwemoyo | Nyamavhuvhu 2011 | Phase 3 |
| NCT04288700 | Ain Shams University | Infantile Hemangioma | Gumiguru 1, 2019 | Chikamu chechina |
| NCT00223717 | Vanderbilt University|Vanderbilt University Medical Center | Hypertension | Ndira 2001 | Phase 1 |
| NCT02770378 | Yunivhesiti yeUlm | Yakavimbika Cancer Therapies|Anticancer Fund, Belgium | Glioblastoma | Mbudzi 2016 | Chikamu 1 | Chikamu 2 |
| NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | Preeclampsia | Ndira 2013 | Chikamu chechina |
| NCT01545479 | Instituto de Cardiologia muRio Grande kuita Sul | Renal Disease | Ndira 2010 | Chikamu chechina |
| NCT00935805 | Hospital de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico e Tecnológico|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil | Chirwere cheshuga mellitus | Arterial Hypertension | Chikunguru 2006 |
|
| NCT00742040 | Chipatara Chevana Vanorwara | Chirwere chemoyo | Nyamavhuvhu 2008 | Phase 2 |
| NCT03613506 | Wuhan University | Radiotherapy Side Effect | Kutora Captopril | Gumiguru 25, 2018 | Phase 2 |
| NCT00004230 | Northwestern University | National Cancer Institute (NCI) | Kenza | Gumiguru 1999 | Phase 3 |
| NCT00660309 | Novartis | Type 2 Diabetes Mellitus | Kubvumbi 2008 | Chikamu chechina |
| NCT00292162 | NHS Greater Glasgow uye Clyde | Kutadza Kwemoyo Kusingaperi | Atrial Fibrillation | Ndira 2007 | Hazvigoneke |
| NCT01271478 | Coordinación de Investigación en Salud, Mexico | Kuzvimba | Kupera-nhanho Renal Chirwere | Nyamavhuvhu 2009 | Chikamu chechina |
| NCT04193137 | Chongqing Medical University | Primary Aldosteronism | Mbudzi 30, 2019 |
|
| NCT00155064 | National Taiwan University Hospital | Hyperaldosteronism | Chikunguru 2002 | Chikamu chechina |
| NCT01292694 | Vanderbilt University|Vanderbilt University Medical Center | Hypertension | Kwakachena Kutadza Kwekuzvimirira | Multiple System Atrophy | Kurume 2011 | Phase 1 |
| NCT00917345 | National Taiwan University Hospital | Novartis | Primary Aldosteronism | Ndira 2008 |
|
| NCT00077064 | Radiation Therapy Oncology Group|National Cancer Institute (NCI)|NRG Oncology | Kenza yemapapu | Matambudziko ePulmonary | Radiation Fibrosis | Chikumi 2003 | Phase 2 |
Storage
| Upfu | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 mwedzi |
| -20°C | 1 mwedzi |
Chimiro chemakemikari
Proposal18Quality Consistency Evaluation mapurojekiti akatenderwa4,uye6mapurojekiti ari pasi pekubvumidzwa.
Yepamberi yepasirese yemhando manejimendi system yakaisa hwaro hwakasimba hwekutengesa.
Kutariswa kwemhando yepamusoro kunofamba kuburikidza nehupenyu hwese kutenderera kwechigadzirwa kuti ive nechokwadi chemhando nekurapa.
Professional Regulatory Affairs timu inotsigira zvinodiwa zvemhando panguva yekushandisa uye kunyoreswa.
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