Ribociclib 1374639-75-4
Tsanangudzo
Ribociclib (LEE01) inonyanya kujeka CDK4/6 inhibitor ine IC50 kukosha kwe10 nM uye 39 nM, zvichiteerana, uye inodarika chiuru-yakapetwa isina simba kurwisa cyclin B/CDK1 yakaoma.
In Vitro
Kurapa mapaneru e17 neuroblastoma cell mitsara neRibociclib (LEE011) pane mana-log dose renji (10 kusvika 10,000 nM). Kurapa neRibociclib kunovharisa zvakanyanya substrate adherent kukura maererano nekutonga mu12 ye17 neuroblastoma cell mitsara yakaongororwa (zvinoreva IC50=306±68 nM, tichifunga mitsara yakaoma chete, apo kunzwa kunotsanangurwa seIC50 isingasviki 1.μM. Ribociclib kurapwa kweviri neuroblastoma cell lines (BE2C uye IMR5) nekuratidzira kunzwisiswa kuCDK4/6 inhibition inoguma mukuunganidzwa-kunoenderana nedosi kuunganidzwa kwemasero muG0/G1 chikamu chesero cycle. Uku kusungwa kweG0/G1 kunova kwakakosha paRibociclib concentrations ye100 nM (p=0.007) uye 250 nM (p=0.01), zvichiteerana.
CB17 immunodeficient mice dzine BE2C, NB-1643 (MYCN amplified, sensitive in vitro), kana EBC1 (isina-amplified, resistant in vitro) xenografts inorapwa kamwe chete zuva nezuva kwemazuva 21 neRibociclib (LEE011; 200 mg/kg) kana ne kutonga kwemotokari. Iri dosing zano rinotenderwa zvakanaka, sezvo pasina uremu kana zvimwe zviratidzo zvechepfu zvinoonekwa mune chero yemhando yexenograft. Kukura kwebundu kunonyanya kunonoka mukati memazuva makumi maviri nerimwe ekurapwa mumakonzo ane BE2C kana 1643 xenografts (zvose, p <0.0001), kunyange zvazvo kukura kwakatangazve mushure mekurapa.
Storage
| Upfu | -20°C | 3 years |
| 4°C | 2 years | |
| In solvent | -80°C | 6 mwedzi |
| -20°C | Mwedzi 1 |
Chimiro chemakemikari
Proposal18Quality Consistency Evaluation mapurojekiti akatenderwa4,uye6mapurojekiti ari pasi pekubvumidzwa.
Yepamberi yepasirese yemhando manejimendi system yakaisa hwaro hwakasimba hwekutengesa.
Kutariswa kwemhando yepamusoro kunomhanya kuburikidza nehupenyu hwese kutenderera kwechigadzirwa kuti ive nechokwadi chemhando uye yekurapa maitiro.
Professional Regulatory Affairs timu inotsigira zvinodiwa zvemhando panguva yekushandisa uye kunyoreswa.
Korea Countec Bottled Packaging Line
Taiwan CVC Bottled Packaging Line
Italy CAM Board Packaging Line
German Fette Compacting Machine
Japan Viswill Tablet Detector
DCS Control Room
