Sacubitril Hemicalcium
| 沙库比曲半钙盐 | Sacubitril Hemicalcium | 1369773-39-6 | Mumba |
| 沙库比曲钠盐 | 149690-05-1 | Mumba | |
| LCZ-4 | 1426129-50-1 | Mumba | |
| LCZ-7 | 1012341-48-8 | Mumba | |
| LCZ-8 | 1012341-50-2 | Mumba | |
| LCZ-9 | 149690-12-0 | Mumba |
Background
AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. Iyo inhibitor ye neprilysin ine IC50 kukosha kwe5 nM [1].
AHU-377 uye angiotensin II AT1 receptor antagonist valsartan vanogadzira LCZ696 mu 1: 1 molar ratio. LCZ696 inonzi angiotensin receptor neprilysin inhibitor. Inogona kuderedza BP uye inogona kuva mushonga mutsva wekurapa kutadza kwemoyo. AHU-377 ndeye pro-drug, inogona kushandurwa ne enzymatic cleavage ye ethyl ester kuita inoshanda fomu LBQ657. Zvinonzi AHU-377 (30 uye 100 mg/kg, PO) inogona kukonzera antihypertensive mhedzisiro nenzira inotsamira mudhamu mumakonzo eDAHI-SS. Asi muDOCA-munyu hypertensive rats, inoratidza kuderera kusina simba [2, 3].
References:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Basa rinogona kuitwa re valsartan + AHU377 (LCZ696) mukurapa kwekushaya mwoyo. Nyanzvi Opin Investig Zvinodhaka. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Kuenzanisa kushanda kweAHU-377, ine simba neprilysin inhibitor, mumakonzo maviri emhando-inotsamira hypertension. BMC Pharmacology 2011, 11(Suppl 1):P33.
Chimiro chemakemikari
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