Sacubitril Hemicalcium

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Sacubitril Hemicalcium   Mumba      

Chigadzirwa Chigadzirwa

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CHIDZIDZO CHIDZIDZO

    曲 库 比 钙盐 钙盐 Sacubitril Hemicalcium 1369773-39-6 Mumba
    库 比 曲 钠盐 149690-05-1 Mumba
    LCZ-4 1426129-50-1 Mumba
    LCZ-7 1012341-48-8 Mumba
    LCZ-8 1012341-50-2 Mumba
    LCZ-9 149690-12-0 Mumba

 

Mhemberero

AHU-377 hemicalcium munyu ndeye hemicalcium munyu fomu yeAHU-377. Iyo inhibitor ye neprilysin ine IC50 kukosha kwe5 nM [1].

AHU-377 uye angiotensin II AT1 receptor anopikisa valsartan vanonyora LCZ696 mune 1: 1 molar ratio. LCZ696 ndeye angiotensin receptor neprilysin inhibitor. Inogona kudzikisa BP uye inogona kuve inoverengeka mushonga wekurapa kwekutadza kwemoyo. AHU-377 ndeye pro-chinodhaka, inogona kushandurwa ne enzymatic cleavage ye ethyl ester muiyo inoshanda fomu LBQ657. Zvinonzi AHU-377 (30 uye 100 mg / kg, PO) inogona kukonzera antihypertensive mhedzisiro-inoenderana nedosi-in rats muDAHI-SS makonzo. Asi mune DOCA-munyu hypertensive makonzo, inoratidza kushomeka kushoma [2, 3].

Zvinyorwa:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide kwazvakarerekera endopeptidase inhibitors. J Med Chem. 1995 Chivabvu 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Rinogona kuita basa revalsartan + AHU377 (LCZ696) mukurapa kwekutadza kwemoyo. Nyanzvi Opin Investig Zvinodhaka. 2013 Aug; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Kuenzanisa kushanda kweAHU-377, ine simba neprilysin inhibitor, mumakonzo maviri emhando yehuwandu-inoenderana neBP. BMC Pharmacology 2011, 11 (Suppl 1): P33.

Chimiro chemakemikari

Sacubitril Hemicalcium

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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