Tsanangudzo

Sugammadex sodium inogadzirwa neγ-cyclodextrin inotorwa, uye inoshanda sechinhu chitsva chinodzosera cheneuromuscular block.

Generic Zita: sugammadex (soo GAM ma dex)
Zita reBrand: Bridion

Sugammadex inodzosera mhedzisiro yeimwe mishonga inopihwa panguva yekuvhiya kuzorodza tsandanyama dzako.

Sugammadex inoshandiswa pakupera kwekuvhiyiwa, kubatsira kudzorera mhasuru basa rakavharwa panguva yekuvhiyiwa nemimwe mishonga.

Sugammadex inogonawo kushandiswa kune zvinangwa zvisina kunyorwa mugwaro remishonga.

Inoshandiswa kudzosera mhedzisiro yemamwe madhiragi.

MuVivo

Jekiseni ye sugammadex haina mhedzisiro yakakosha paBP kana kurova kwemoyo. Mushure mejekiseni repamusoro rocuronium dose, iyo 90% kudzoreredza yechitima-ye-china chiyero inotora 28 min (SD 7 min) mushure mesaline, 26 min (SD 9.5 min) mushure me1 mg / kg sugammadex, uye 8 min (SD 3.6 min) mushure me2.5 mg / kg sugammadex [1]. Sugammadex inokonzera kukurumidza uye kwakazara kutendeuka kwe rocuronium-induced neuromuscular block. Nguva yekudzoreredza yekudzidzisa yechina ratio = 0.9 mushure mekudzoreredza kupora ndeye 14.4 min (SD = 3.4 min; n = 14). Izvi zvakaderedzwa zvakanyanya kusvika ku3.7 min (SD = 3.3 min; n = 4) ne sugammadex 0.5 mg / kg uye ku 1.9 min (SD = 1.0 min; n = 4) ne sugammadex 1.0 mg / kg [2]. Iyo inofungidzirwa hafu yehupenyu hwe sugammadex muRhesus monkey ndeye 30 (SEM = 4.9) min[3].

Storage

Chimiro chemakemikari